Dynactin 1 anticorps (AA 1228-1278)

N° du produit ABIN7451920

Cet anticorps Lapin Polyclonal détecte spécifiquement Dynactin 1 dans WB et IP. Il présente une réactivité envers Humain et Souris.

Aperçu rapide pour Dynactin 1 anticorps (AA 1228-1278) (ABIN7451920)

Antigène: Dynactin 1 (DCTN1)

Reactivité: Humain, Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp Dynactin 1 est non-conjugé

Application: Western Blotting (WB), Immunoprecipitation (IP)

Détail du produit anti-Dynactin 1 anticorps

Épitope: AA 1228-1278

Fonction: Rabbit anti-p150glued Antibody, Affinity Purified

Purification: Affinity Purified

Immunogène: between AA 1228 and 1278

Isotype: IgG

Information d'application

Indications d'application:

IP: 2 - 5 μg/mg lysate

WB: 1:2,000 - 1:10,000

Restrictions: For Research Use only

Stockage

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C

Date de péremption: 12 months

Détails sur Dynactin 1

Antigène: Dynactin 1 (DCTN1)

Autre désignation: p150glued

Sujet: Background: p150glued is the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. The p150glued subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus [taken from NCBI Entrez Gene (Gene ID: 1639)].

ID gène: 1639

NCBI Accession: NP_004073

UniProt: Q14203

Pathways: M Phase, ER-Nucleus Signaling